Graceful Earth Inc. - Alzheimer's Test-FAQ

QUESTIONS & ANSWERS REGARDING THE ALZHEIMER'S AOPE GENOME TEST FROM OUR DOCTORS
	WHAT IS THE APOE GENOME?
The APOE genome is responsible for the formation of lipid molecules in the blood, which are then utilized in metabolic processes in the human body.

	HOW OR WHY DOES THIS GENOME PUT A PERSON AT RISK FOR DEVELOPING ALZHEIMER'S DISEASE?

Genetic abbreviations in the APOE gene alter the 3-dimensional formation of the lipid molecules, so that they cannot be fully used in metabolic processes. Depending on the genetic abbreviation, the person is at higher risk for Alzheimer's disease and / or Atherosclerosis.

	EXPLAIN WHAT A PERSON HAS TO DO TO TAKE THIS SALIVA TEST.

The person has to put a small amount of saliva on a piece of filter paper and then dry the filter paper. When the filter paper is dry, the DNA in the saliva is stable for years and can be easily sent to the laboratory.

	CAN YOU SHOW US OR EXPLAIN TO US HOW THE MACHINE WORKS?
1. The DNA from the dried filter paper is isolated.
2. The APOE gene is then amplified (enriched) in a Polymerase Chain Reaction (PCR) a couple of billion times.
3. The significant mutation sites are detected either by color reaction and / or enzymatically.

	IF A PERSON IS AT RISK FOR ALZHEIMER'S, WHAT KIND OF LIFESTYLE CHANGES SHOULD THEY BE MAKING?

Physical exercise and increased consumption of vegetables and fruits should be favored. Essential fatty acids in the blood and also lipid-peroxidation parameters should be checked every 6-12 months.

	HAVE THESE LIFESTYLE CHANGES BEEN PROVEN TO REDUCE THE RISK OF DEVELOPING ALZHEIMER担 DISEASE・HOW SO?

Numerous international publications describe this.

	EXPLAIN TO US THE DIFFERENT FORMS OF THE APOE GENOME.

1. E2/E2 - Best protection from Alzheimer 's Disease. Risk for Atherosclerosis (risk diminished).
2. E2/E3 - Risk for Atherosclerosis but very low risk for Alzheimer's Disease
3. E2/E4 -Risk for Alzheimer's Disease and for Atherosclerosis.
4. E3/E3 - Normal type (moderate protection from both Alzheimer's Disease and Atherosclerosis).
5. E3/E4 - Moderate risk for Alzheimer's Disease and Atherosclerosis
6. E4/E4 -Severe risk for Alzheimer's Disease and Atherosclerosis.
	WHY IS THIS NEW TEST SO IMPORTANT?

You can identify at-risk persons well before the disease starts. This provides the important possibility of prevention. In cases where the disease is already in progress, you can stop the disease in its early stages.

	IS THERE ANYTHING ELSE YOU'D LIKE TO ADD?

Routine check (6-12 months) of lipid-peroxidation parameters and essentioal fatty acids in the blood are important for at-risk persons. This will evaluate the effectiveness of the preventive measures and /or therapy.

Apolipoprotein E (apoE) plays an important role in the metabolism and redistribution of lipoproteins and cholesterol.

ApoE plays a major role in detoxifying HNE and the neuroprotective effects of its isoforms may help explain the relationship between apoE genotype and the susceptibility to neurodegenerative diseases.

When you receive the kit, mail in your specimen. After your specimen is received please expect 3-4 weeks for completion.

Alzheimer's Test-FAQ

QUESTIONS & ANSWERS REGARDING THE ALZHEIMER'S AOPE GENOME TEST FROM OUR DOCTORS

DNA Analysis by Graceful Earth Inc.